ABSTRACT
Andrographis paniculata (Acanthaceae) has been used to treat hepatoprotective, antidiarrhoeal, antiinflammatory, antimalarial, and antihypertensive. The aim of the study was to investigate the antifungal activity of different part of extracts of A. paniculata. The antifungal activity of extracts of A. paniculata was evaluated by Agar well diffusion method against five selected fungal species. Stem extracts of A. paniculata showed high antifungal activity against A.oryzae, Penicillum sp and C.albicans. The root extracts showed high antifungal activity against A. niger, A. flavus, C.albicans, Penicillum sp and A.oryzae and also leaf extracts showed high antifungal activity against Penicillum sp and A. flavus but did not show antifungal activity against C.albicans, A. niger, A.oryzae. The results obtained in the present study suggest that A. paniculata plant can be used in treating various diseases caused by the test organisms.
ABSTRACT
Purpura Fulminans is a severe disorder of acute onset with high morbidity and mortality. It is characterized by DIC with thrombocytopenia, hyofibrinogenemia, hypothrombinemia and anemia. It most often occurs in young with sudden appearance of symmetrical, tender, ecchymotic skin lesions usually involving the lower extremities. An infectious and noninfectious etiology has been proposed. Early recognition and early therapy with appropriate antibiotics and heparin is known to limit both morbidity and mortality. This article reports 5 cases of Purpura Fulminans treated at our centre with review of etiology, pathogenesis, clinical features and treatment.